Studies on fat-storing cells. I. Ingestion of Triton WR-1339 by fat-storing cells.
نویسندگان
چکیده
منابع مشابه
Fat - storing Cells as Liver - specific
Liver perisinusoidal fat-storing cells (FSC) show morphological and ultrastructural characteristics similar to pericytes regulating local blood flow in other organs. In the present study we have analyzed whether FSC respond to local vasoconstrictors such as thrombin, angiotensin-II, and endothelin-1 with an increase in intracellular free calcium concentration (ICa2I1I) coupled with effective ce...
متن کاملAcceleration of Hepatic Cholesterol Synthesis by Triton Wr-1339
Synthesis of cholesterol from acetate in the rat was studied after injection of triton WR-1339, both in the whole animal and by the liver slice technique. Synthesis appeared to be increased 3-fold 24 hours after the injection. It was depressed after 72 hours, concurrently with a rise in the cholesterol concentration in the liver and its fall towards normal in the blood. When triton was injected...
متن کاملCultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.
Monocytes infiltrate the portal space during chronic liver inflammation. Monocyte chemotactic protein-1 (MCP-1) is a cytokine that induces monocyte chemotaxis and activation. We investigated if human liver fat-storing cells (FSC) secrete MCP-1, and the mechanisms that regulate MCP-1 production. Unstimulated FSC secrete MCP-1 as measured by radioimmunoassay as well as a chemotactic assay and exp...
متن کاملStudies on the Effect of Triton (wr-1339) on Guinea Pig Tissues
The administration of triton WR-1339 (300 mg./kg. subcutaneously) to tuberculin-sensitive guinea pigs 2 hours before the intradermal injection of PPD depresses slightly their skin sensitivity to tuberculin and essentially obliterates the lytic effect of tuberculin on their circulating leucocytes. When leucocytes from tuberculin-sensitive guinea pigs are exposed to triton in vitro at a concentra...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1981
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.57.282